We previously determined, first, that metabolic endotoxemia controls the. Propensity to highfat dietinduced obesity in rats is. Interestingly, oxytocin and oxytocin receptordeficient mice develop lateonset obesity with normal food intake. Obesity is rapidly becoming a worldwide epidemic that affects children and adults. Background overweight and abdominal obesity, in addition to medical conditions such as high blood pressure, high blood sugar and triglyceride levels, are typical risk factors associated with. Germinated brown rice ameliorates obesity in highfat diet.
Abstractalthough obesity is a risk factor for hypertension, the relationship between these 2 conditions is not well understood. Diet induced obesity an overview sciencedirect topics. The consumption of a highfat diet hfd is considered a risk factor for. The hedinduced rat has been widely used as a model for the evaluation of hyperlipidemic prevention and has many similarities between the metabolism diseases observed in hedinduced rats. We developed a rat model of dietinduced obesity that will be a powerful tool for assessment of this issue. Cardamom powder supplementation prevents obesity, improves. The model of dietinduced obesity in rodents can be considered effective when the. Development of hypertension in a rat model of dietinduced. Obesity is a risk factor for chronic kidney disease ckd. Antiobesity and hypolipidemic activity of moringa oleifera. After receiving their respective diet for 10 weeks, the obese induced rats gained significantly higher body weight and bmi than the negative control rats, thus verified to be obese. Obesity is a leading public health problem worldwide. Highfat dietinduced obesity in animal models niloofar hariri and louise thibault school of dietetics and human nutrition, mcgill university, quebec, canada epidemiological studies have shown a.
A rat model to study the effects of dietinduced obesity. The dietinduced obesity model dio model is an animal model used to study obesity using animals that have obesity caused by being fed highfat or highdensity diets. Lewcrl rats fed a 60% kcal hfd become obese, but they lack significant metabolic abnormalities frequently associated with obesity in other rat strains. Biometric evidence of dietinduced obesity in lewcrl rats article pdf available in comparative medicine 612. Highfat dietinduced metabolic syndrome and oxidative. This study aimed to examine the effect of low dose. In the present experiments, the effect of dhea treatment in rats with dietinduced obesity was evaluated. In the past decades, obesity and associated metabolic complications have reached epidemic proportions. In four experiments, longevans rats ate ad libitum a. Pdf dietinduced obesity in rats leads to a decrease in sperm. Green coffee extract modifies body weight, serum lipids. Kefir peptides prevent hyperlipidemia and obesity in high.
Nonetheless, a causal role of dietary fat has never been documented, because of. Abstractinsulin acts in the hypothalamus, decreasing food intake fi by the irpi3kakt pathway. The effect of highfat dietinduced obesity on cardiovascular toxicity. Recent work suggests that obesity may adversely affect cognitive behavior. Dietinduced obesity in rats leads to a decrease in. For the study of these pathologies, a number of animal models have been. A polyphenolrich cranberry extract protects from diet. Cardiovascular function in a rat model of dietinduced obesity. Obesity has reached epidemic proportions worldwide. Antiobesity effect of lactobacillus gasseri bnr17 in high.
This dietaryinduced obesity dio prone rat model of obesity is a outbred, albino, and polygenic model. As mentioned in table 3, it has been observed that rats feed on highfat diet consecutively for 21 days resulted in a marked increase in the level of. Obesity induced by highfat diet in female rats structurally and. In humans, a hyperactivity of glucocorticoid metabolism was postulated to be involved in the intrauterine programming of the metabolic syndrome in adulthood. Effect of carnitine and herbal mixture extract on obesity induced by high fat diet in rats. This study aims to evaluate antiobesity effects of gbr. Highfat dietinduced metabolic syndrome and oxidative stress in. The effects of gmf supplementation on dietary intake, body weight and bmi in highfat dietinduced obese rats was shown in table 1. Objective the increasing prevalence of obesity and type 2 diabetes t2d demonstrates the failure of conventional treatments to curb these diseases. Article information, pdf download for the effect of highfat dietinduced obesity on. Diet induced obese dio mouse models c57bl6ntac male. Dietinduced obesity and spatial cognition in young male rats. A controlled highfat diet induces an obese syndrome in rats.
Biometric evidence of dietinduced obesity in lewcrl rats ncbi. While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. Effect of consumption of a highfat hf diet on body weight, adiposity, and food intake in lowfat lf and hffed animals after 8 or 12 wk on respective diets a. Dietinduced adipocyte number increase in adult rats. The effect of diet and exercise on intestinal integrity and microbial diversity in mice. Protective effects of tamarillo cyphomandra betacea. Germinated brown rice gbr is a novel functional food that is high in fiber and bioactive compounds with healthpromoting properties. Cardiovascular function in rat model of dietinduced obesity. The rat is a useful model for the study of obesity because the obesity is expressed only when the rats are fed a diet moderately high in energy and fat content. Antiobesity effects of aster spathulifolius extract in. Wet weight and cellularity of dissected adipose depots of adult rats fed a highfat diet for 5 mo gonadal bdy wt, retroperitmeal. Therefore, we examined some parameters of hypertension and cardiovascular. Oxidative stress in a rat model of obesityinduced hypertension.
Highfat dietinduced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation skip to main content thank you for visiting. Effects of dehydroepiandrosterone treatment in rats with. In experiment 1, male spraguedawley rats 300 g were fed a nonpurified diet. Dosedependent and straindependent antiobesity effects. Beneficial effects of cocoa, coffee, green tea, and. Related publications genetic determinants of energy expenditure and insulin resistance in dietinduced obesity in mice. Our goal was to develop an animal model to study the relationship by combining two existing spraguedawley rat models of radiationinduced mammary carcinogenesis and dietinduced. Highfat dietinduced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation.
Rat models of dietinduced obesity and high fatlow dose. Treating obese and diabetic rats with enalapril or a menhaden oil enriched diet generally improved peripheral neuropathy endpoints. Some studies have shown a relationship between obesity and infertility, but until now it remains. We hypothesized that excess fuel supply in a rat model of dietinduced obesity leads to myocardial cell damage due to increased oxidative stress and apoptosis. Obesity is a complex metabolic disorder that is linked to numerous serious health complications with high morbidity. Dietinduced obesity in rats leads to a decrease in sperm. The current investigation was untaken to evaluate the. Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. To examine this suggestion, the effects of feeding a standard chow diet, and either supplemental sugar or fat on the development. Cardamom is a wellknown spice in indian subcontinent, used in culinary and traditional medicine practices since ancient times. Whether alterations in brain reward sensitivity precede. Apart from its role during labor and lactation, oxytocin is involved in several other functions.
Over the last two decades, we and others have employed an outbred rat model to study the development and persistence of obesity, as well as. Rats vary in their propensity to become obese when eating a highfat diet, but the factors that make some rats susceptible and others resistant to dietinduced obesity are unclear. Pdf highfat dietinduced obesity in animal models researchgate. Highfat dietinduced obesity causes an inflammatory. Modeling dietinduced obesity with obesityprone rats. Previously, we reported that lactobacillus gasseri bnr17 bnr17, a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue weight in. In dietinduced obese male mice decreases in sperm motility 16,17. Effect of highfat dietinduced obesity on thyroid gland. Since rats and mice show a similar relationship, they are considered an appropriate model for studying dietary obesity. Impact of chromium histidinate on high fat diet induced. Objective diabetes and obesity are characterized by a lowgrade inflammation whose molecular origin is unknown.
Multiple lines of evidence associate deficits in the brain reward circuit with obesity. Mangosteen garcinia mangostana flesh supplementation. Mechanisms of the antiobesity effects of oxytocin in diet. Pdf biometric evidence of dietinduced obesity in lew. Ultimate force was similar between groups figure 4 b, while. The major factors that contribute to dietary obesity hyperphagia, energy. Highfat dietinduced obesity in animal models nutrition. Reduced hepatocyte fatty acid oxidation in outbred rats. In group iii, the biochemical parameters and structure of thyroid follicles were improved, and they had a nearnormal appearance. Download fulltext pdf download fulltext pdf dietinduced obesity in rats leads to a decrease in sperm motility article pdf available in reproductive biology and endocrinology 91. The aim of this study was to investigate the antiobesity and antihyperlipidemic efficacy and molecular mechanisms of aster spathulifolius maxim extract ase in rats with highfat diet hfd.